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Report teachingOct 2, 2026
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…tigue, and brain fog can arise from many conditions. Immune signals such as TNF-alpha and IL-6 are relevant to some inflammatory illnesses, but symptoms alone cannot identify the cause. Follow the pathway Dr. Purser explains the relationsh…

Report teachingOct 2, 2026
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…ects epithelial injury, fibroblasts, TGF-beta, inflammatory signals, and oxidative stress with scar formation. He discusses the difference between reducing inflammation and treating a fibrotic process; antioxidant mechanisms do not prove re…

Report teachingOct 2, 2026
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… pigment-producing melanocytes in areas of the skin. Immune signals can help recruit and maintain cells that participate in this process. Follow the pathway Dr. Purser follows the IFN-gamma pathway through CXCL9 and CXCL10, which guide imm…

Report teachingOct 2, 2026
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…ment, antibodies, or other tests would help distinguish the type. Persistent sores or marked pain need medical attention, alongside practical strategies for warmth and trigger reduction.

Report teachingOct 2, 2026
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… rs4633 alongside regulatory and linked variants such as rs6269, rs4818, rs4646312, and rs165722. He connects COMT with stress response, pain sensitivity, sleep, and estrogen processing. Linked groups of variants are called haplotypes; a la…

Report teachingOct 2, 2026
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…lin. After insulin binds, the receptor activates a chain of signals that influences glucose uptake and metabolism. Follow the pathway Dr. Purser follows the receptor through IRS proteins, PI3K/AKT, and glucose transport. He discusses magne…

Report teachingOct 2, 2026
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…ay Dr. Purser discusses IL-6, TNF-alpha, other inflammatory signals, tissue remodeling, and the interaction between inflammation and hormone-related processes. Cytokines are one part of the picture, rather than a substitute for a gynecologi…

Report teachingOct 2, 2026
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…e pathway Dr. Purser discusses TNF-alpha, IL-6, IL-1 family signals, and Th17/Th22 pathways in eye inflammation. The degree of eye disease cannot be inferred simply from whether a common genetic finding is heterozygous or homozygous. Bring…

Report teachingOct 2, 2026
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…the pathway Dr. Purser connects endothelial changes, immune signals, TGF-beta-related fibrosis, and Raynaud’s phenomenon. Tissue scarring and inflammatory activity are related but do not mean every symptom has the same cause. Bring these q…

Nutrient referenceSep 23, 2026
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… not prove a clinical benefit. Glutathione and inflammatory signals Glutathione helps your cells respond to oxidative stress. In Dr. Purser’s model, this may also connect with immune signals called IL-8 and MCP-1. This is one reason he look…

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