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A subscriber post from Purser Wellness on Substack, covering cytokines and immune signaling, inflammation and antioxidants.

Feeling exhausted and super sensitive to supplements? 😩 You might think it’s adrenal fatigue, but in many cases, it’s actually due to vitamin deficiencies—especially in those with MTHFR or FOLR2 gene mutations. These genetic variants can im

Wondering if Hashimoto’s is hyper or hypothyroidism? It usually starts as hyper for a short time but almost always transitions to hypothyroidism. The key to treatment? Don’t just chase labs—treat based on how the patient feels. Cold hands,

Think scurvy is a thing of the past? 🏴‍☠️ Think again—it’s very real in modern America. Dr. Purser diagnosed 7 cases last year alone, and several already this year. If you’re dealing with bleeding gums, extreme fatigue, weird anemia, fibrom

Always exhausted no matter how much you rest? 😩 It’s likely not “adrenal fatigue”—it’s usually vitamin deficiencies affecting your adrenal and pituitary function. A CMA with Redox panel can reveal what your cells are missing. It’s helped th

Let’s talk about something uncomfortable but important—anal fissures, especially in people with Crohn’s disease or ulcerative colitis. These painful tears can extend deep and cause debilitating discomfort. Historically, treatments haven’t w

Ever heard of glutathione? It’s called the “master antioxidant” for a reason—it supports detox, reduces inflammation, and protects every cell in your body from oxidative damage. 🧬 If you have high homocysteine or MTHFR gene variants, chance

What is SOD and why should you care? 🧬 Superoxide Dismutase (SOD) is your body’s first line of defense against oxidative stress—neutralizing harmful radicals from breathing, metabolism, and even sunlight exposure. It’s the first enzyme in y

Been told you have chronic fatigue syndrome (CFS) and handed a prescription for antidepressants or stimulants? 😤 The truth is, CFS is often a result of deep vitamin and nutrient deficiencies, not a mental health issue. Most cases I see come

If you’re dealing with POTS (Postural Orthostatic Tachycardia Syndrome) and constantly feeling dizzy, lightheaded, or weak, it could be more than just your nervous system—it might be intracellular vitamin deficiencies. The top five we see a

Ever heard of MTHFR? No, it’s not a swear word—it’s a common genetic mutation that affects your body’s ability to methylate folate and produce energy from carbs. If you have the C677T or A1298C SNPs, it can lead to fatigue, brain fog, high

Premature Ovarian Insufficiency (POI) – There’s a Treatment! POI, or premature ovarian insufficiency, can be a big issue for many women, but it does have a treatment. By addressing intracellular vitamin, mineral, and amino acid deficiencies