Let’s explore “MCP-1”

PURSER WELLNESSAutism Answered - Root Cause Solved with #1 Reviewed MD in the USAA conversation with Dr. Purser

Hi, I’m Dr. Dan Purser. For too long, autism has been treated as a mystery with only symptom management. In this episode, I break down what I’ve seen consistently in practice: the real root cause behind many cases on the spectrum. It starts with genetic variants (especially MTHFR and related SNPs) that break the transsulfuration pathway. When kids can’t efficiently convert homocysteine into glutathione, they lose their ability to detox heavy metals and environmental toxins. The result is chronic inflammation, oxidative stress, and developmental challenges. The good news? Once we identify these biochemical and genetic imbalances through proper testing, we can intervene at the root with targeted support — restoring methylation, rebuilding glutathione function, and giving the body what it needs to heal. This isn’t theory. It’s the Purser Method® in action. If you’re a parent searching for real answers instead of just labels, this episode is for you. The root cause has been solved. Now let’s talk solutions.

PURSER WELLNESSIt's not homocysteine—it’s the cytokines #substack #shortsA conversation with Dr. Purser

This is a clip from https://danpursermd.substack.com/p/purser-wellness-open-house-livestream?utm_source=youtube_shorts See the full video: https://www.youtube.com/watch?v=Zg35UGvVlwU #shorts #substack

PURSER WELLNESSPurser Wellness Open House Livestream Recap: Root-Cause Medicine, Breakthroughs in Inflammation & RA conversation with Dr. Purser

… worry about the homocyine. You worry about the ILA and the MCP1, the two cytoines it produces. That's what kill you. That's what causes those death. You get into a flare u and it can shut down your kidneys. It can cause a heart attack or s…

PURSER WELLNESSPurser Wellness Open House | Livestream with Dan Purser MD and Team!A conversation with Dr. Purser

… worry about the homocyine. You worry about the ILA and the MCP1, the two codicons it produces. That's what kill you. That's what causes those death. You get into a flare and it can shut down your kidneys. It can cause a heart attack or str…

PURSER WELLNESSHow to Properly Treat Kids: Root Cause Medicine for Autism, ADHD, and Developmental ChallengesA conversation with Dr. Purser

In this powerful live session, Dr. Dan Purser MD reveals why conventional pediatric medicine often falls short and shares his proven Purser Method® for helping children with autism spectrum traits, severe ADHD, chronic inflammation, and developmental delays. Drawing from over 43 years of clinical experience, Dr. Purser explains: Why genetic testing (especially MTHFR and related SNPs) is the essential first step How to use targeted, active-form nutrients instead of generic vitamins The role of leucovorin (high-dose folinic acid) and when it makes a real difference Practical ways to reduce toxin load and calm the inflammatory response Smart strategies around vaccination and detoxification support Dr. Purser emphasizes that kids are not little adults — their developing systems need precise, individualized care. Parents and practitioners will walk away with actionable steps that address root causes rather than just managing symptoms. Whether your child is struggling with speech delays, meltdowns, focus issues, or recurrent health problems, this episode offers real hope through biochemistry done right. Resources Mentioned: Pediatric MTHFR formulas: https://www.PhysicianDesigned.com Book a consultation: http://www.DanPurserMD.com Dr. Purser’s books on Amazon: https://www.amazon.com/-/e/B00BIKSGVQ If you’re a parent tired of “there’s nothing more we can do,” or a practitioner looking for better tools, this episode is for you. Timestamps available in the full video. Subscribe, leave a review, and share this with any parent who needs to hear it. The kids deserve better answers. Dan Purser MD – Root Cause Inflammation & Genetic Optimization #MTHFR #Autism #ADHD #ChildrensHealth #Leucovorin #FunctionalMedicine #Pediatrics Follow Dr. Purser! Info: http://www.DanPurserMD.com Supplements: https://www.PhysicianDesigned.com Books: https://www.amazon.com/-/e/B00BIKSGVQ Facebook: https://www.facebook.com/danpursermd Facebook: https://www.facebook.com/PhysicianDesigned Twitter: https://twitter.com/realdanpursermd YouTube: https://www.youtube.com/danpursermd Instagram: https://www.instagram.com/danpurser.md Pinterest: https://www.pinterest.com/danpursermd

PURSER WELLNESSCan Glutathione Reverse Kidney Disease, Lower Blood Pressure, and Calm Cytokine Storms? What High HA conversation with Dr. Purser

…cyine from causing the monocytes to release the IL8 and the MCP1. We can assume there's no real way to check an MCP-1 level a huge scientific expense. But IL8 you can easily get I think it's around $50. Check your level, confirm it. You may…

PURSER WELLNESSGlutathione: The Treatment You Need #substack #shortsA conversation with Dr. Purser

This is a clip from https://danpursermd.substack.com/p/high-homocysteine-mthfr-mutations?utm_source=youtube_shorts See the full video: https://www.youtube.com/watch?v=HuQbQ1IqNIM #shorts #substack

PURSER WELLNESSThe Hidden Molecule Driving Inflammation: Understanding the Purser Model of HomocysteineFrom the reading room

Most people have never heard of homocysteine, yet this small molecule may hold the key to understanding inflammation, cardiovascular disease, neurological problems, and many chronic conditions. For decades, homocysteine was viewed as a toxic substance in the blood. Doctors were taught that lowering it with B-vitamins might reduce heart disease risk. But research results were inconsistent, leaving many physicians unsure whether homocysteine truly mattered. New research and clinical observations are changing that view. We introduce a new framework called the Purser Model, which explains why homo

PURSER WELLNESSMTHFR Mutations, Elevated Homocysteine & Autoimmune Inflammation: The Hidden Root Cause Most Doctors MissFrom the reading room

— A Guide by the World’s Leading Homocysteine Expert For more than four decades as a practicing physician, I have watched thousands of patients cycle through conventional autoimmune treatments that address symptoms but never touch the fire underneath. Rheumatoid arthritis flares, lupus rashes, multiple sclerosis relapses, Hashimoto’s thyroiditis, fibromyalgia pain—these are not random. They share a common, often overlooked biochemical pathway: MTHFR mutations leading to elevated homocysteine that supercharges autoimmune inflammation. This is not fringe theory. It is the clinical reality I have

Understand why Dr. Purser places two experimental research discussions at the center of his inflammatory model.

This chapter places environmental exposures alongside genetics, sulfur metabolism and inflammatory markers.

A reading guide to the chapter proposing a role for glutathione and redox modulation in kidney disease.