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…y to reason deeply. The Reality of MTHFR, Homocysteine, and Cytokines These physicians know almost zero about methylation or the FDA and HHS-approved intracellular micronutrient testing we use with our patients. (Yes, targeted vitamin defic…

…es hepatic stellate cells, fibrosis, and the interaction of cytokines with reactive oxygen species. He follows the antioxidant partnership of glutathione, superoxide dismutase, and catalase while also considering nutrition and the metabolic…

…ause of migraine. Follow the pathway His teaching connects cytokines, homocysteine, oxidative stress, and the trigeminal pain pathway. Conventional migraine discussions include triptans and CGRP-directed therapies; nutrient and antioxidant…

… gut-barrier questions, monocyte activation, and downstream cytokines. Bring these questions to your visit Ask which result is being discussed: a genetic variant, a measured protein level, or a diagnosed condition. How does it fit with you…

…eaching connects IL-10 with macrophages, T cells, and other cytokines instead of labeling every cytokine as simply good or bad. Bring these questions to your visit Ask which result is being discussed: a genetic variant, a measured protein …

…nection IL12B encodes the p40 protein subunit shared by two cytokines: IL-12 and IL-23. IL-12 combines p40 with p35; IL-23 combines p40 with p19. Follow the pathway Dr. Purser explains why the shared p40 subunit connects the Th1 and Th17 i…

…athway helps support Th17 immune cells and their downstream cytokines, including IL-17. Follow the pathway Dr. Purser connects IL-23 receptor signaling with inflammatory bowel disease, psoriasis, and inflammatory joint pathways. Targeting …

…connects TLR4 activation with NF-κB signaling, inflammatory cytokines, and the relationship between gut-barrier function and systemic immune activity. A genetic entry, soluble CD14 result, and evidence of infection describe different aspect…

…homocysteine, and a body-wide amplification of inflammatory cytokines. Homocysteine is not merely a cardiovascular marker. It is a potent “cytokine amplifier.” When levels climb above 10–12 µmol/L (my functional optimum is <7–8 µmol/L), hom…

…eted B vitamins (like MTHFR Daily) are key to balancing the cytokines and deficiencies that come with it.

…r — it’s a toxic byproduct that drives inflammation through cytokines like MCP-1 and IL-8, damaging blood vessels and disrupting hormones. Dr. Purser’s research found up to 17 genetic SNPs that can keep homocysteine high — and whether you h…

…arch shows that restoring glutathione levels can calm these cytokines, reduce inflammation, and possibly change how we approach CF and other chronic inflammatory conditions. Science is catching up — and hope is being restored.