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A subscriber episode exploring questions about MTHFR, nutrient status, and daily energy. Read the public introduction and continue on Substack.

Dan and Jackson discuss methylated B vitamins, the term overmethylation, and questions to ask when your response to a supplement changes.

Dan Purser MD and Jackson Larkin discuss the connections they consider between sugar cravings, cellular energy, and methylation.

PURSER WELLNESSUnderstanding Your CMA with Redox Results: What Those Two Pages Actually MeanA conversation with Dr. Purser

If you’ve had our Cellular Micronutrient Assay (CMA) with Redox testing, chances are you’ve looked at those two pages of results and thought, “Okay... now what does all this actually mean?” You’re not alone. This is one of the questions I hear most often from patients. Let me walk you through exactly what each page shows, how the test works, and why these results are so powerful for creating a truly personalized plan to help you feel your best.

From Brain Fog to Burnout: The Hidden Deficiencies Your Bloodwork Misses. By Dan Purser MD

PURSER WELLNESSMTHFR Mutations, Elevated Homocysteine & Autoimmune Inflammation: The Hidden Root Cause Most Doctors MissFrom the reading room

— A Guide by the World’s Leading Homocysteine Expert For more than four decades as a practicing physician, I have watched thousands of patients cycle through conventional autoimmune treatments that address symptoms but never touch the fire underneath. Rheumatoid arthritis flares, lupus rashes, multiple sclerosis relapses, Hashimoto’s thyroiditis, fibromyalgia pain—these are not random. They share a common, often overlooked biochemical pathway: MTHFR mutations leading to elevated homocysteine that supercharges autoimmune inflammation. This is not fringe theory. It is the clinical reality I have

A episode from Purser Wellness on Substack, covering energy and metabolism, testing and nutrients.

PURSER WELLNESSCoQ10 and Thyroid MedicationA conversation with Dr. Purser

CoQ10 is an important nutrient that improves hypothyroidism and metabolism naturally. Explore how CoQ10 can help you with your energy levels and feel younger!

PURSER WELLNESSThe Hidden Molecule Driving Inflammation: Understanding the Purser Model of HomocysteineFrom the reading room

Most people have never heard of homocysteine, yet this small molecule may hold the key to understanding inflammation, cardiovascular disease, neurological problems, and many chronic conditions. For decades, homocysteine was viewed as a toxic substance in the blood. Doctors were taught that lowering it with B-vitamins might reduce heart disease risk. But research results were inconsistent, leaving many physicians unsure whether homocysteine truly mattered. New research and clinical observations are changing that view. We introduce a new framework called the Purser Model, which explains why homo

PURSER WELLNESSMethylation Errors - Could These Be the Cause of Your Fatigue?A conversation with Dr. Purser

Explore with Dr. Purser how methylation errors may be causing your fatigue. Be sure to check out the End Fibromyalgia with Natural Options Facebook page for more help and tips at facebook.com/NaturalOptionsWithLois/

PURSER WELLNESSWhat is MTHFR? What can YOU do about it?A conversation with Dr. Purser

MTHFR is one of the most studied genetic SNPs, with the two main variants being C677T and A1298C. These changes reduce the body’s ability to process folate and make energy, leaving people exhausted and deficient in key nutrients. Specialized folates, B12 forms, and glutathione can bypass the blockages, and products like MTHFR Daily were designed specifically to fill these nutrient gaps so patients can restore energy and thrive.

PURSER WELLNESSWhat is Intracellular Testing?A conversation with Dr. Purser

Intracellular testing, or the CMA Cellular Micronutrient Assay, measures over 100 vitamins, minerals, amino acids, and antioxidants inside your cells—not just in your blood. Unlike serum tests, which show short-term levels, intracellular testing reveals what your cells have been missing over the last 100 days. Low levels can mean weak enzymes, non-functioning proteins, and accelerated aging. By identifying deficiencies and matching them with the correct nutrient forms for your genetics, you can target fatigue, anxiety, depression, and other chronic issues at the root. Get your CMA by calling o