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…ting tissue and urokinase plasminogen activators. The 4G/5G promoter variation is commonly identified as rs1799889. Follow the pathway Dr. Purser discusses fibrinolysis, the process of dissolving clots, alongside homocysteine and blood-ves…

…enetics. MTHFR is one major piece of that bigger picture. Variants such as C677T and A1298C can influence folate metabolism and methylation. Stop blaming yourself. Start understanding the biology. Support your nutrition. Support met…

…on interferon-gamma production. The same gene can have many variants with different meanings. Follow the pathway Dr. Purser follows IFN-γ signaling into T-cell and macrophage activity and the relationship between inflammation and oxidative…

…r processing, hormone balance, and oxidative stress. Common variants are different from confirmed disease-causing mutations, and a genotype does not directly measure enzyme activity. Bring these questions to your visit Ask how DHEA, DHEAS,…

…or XI deficiency can cause a bleeding disorder, while other variants are studied in relation to higher clotting activity. Follow the pathway Dr. Purser discusses rs2289252, factor XI activity, and the distinction between thrombosis researc…

…teration. Follow the pathway Dr. Purser explores inherited variants, DNA repair, and research associations. The variant’s classification and the clinical context matter more than the gene name alone; a common polymorphism does not establis…

…alance are already struggling (especially if you have MTHFR variants), your body can’t clear toxins as well. That leads to more inflammation, leaky gut, and yes — gluten becoming a bigger problem for more people. If you or someone you love…

…mocysteine expert), the missing link for many is MTHFR gene variants (common in ~85% of people). These impair folate processing → elevated homocysteine → massive inflammation and cytokine storms (IL-6, TNF-α, IL-17, etc.). High homocystein…

…, leading to inefficient methylation. There are two primary variants of the mutation, C677T and A1298C. People can have one or two copies of each mutation (from either or both parents), affecting the function of the MTHFR enzyme to varying …

…erefore cannot produce enough energy in your cells. Certain variants of MTHFR can only produce 12-16 ATP per carb vs a “normal” person being able to produce 32 ATP per carb. And you wonder why you’re tired? Let’s figure this out! You have…

…if any, mutations you may have. Heterozygous and homozygous variants of the genes can cause more intense symptoms of the MTHFR Genetic Mutation. Depending on which mutations you have, your general ATP production will be reduced compared to …

…rm of folate used in the processing of homocysteine. Common variants are different from rare variants that cause severe MTHFR deficiency. Topics: homocysteine, homocystinuria, B vitamins, cardiovascular risk, methionine, methylation