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IL18 encodes interleukin-18, a cytokine that can promote interferon-gamma responses in the appropriate immune context. Its receptor includes components encoded by IL18R1 and IL18RAP.

IL1B encodes interleukin-1 beta, a cytokine involved in inflammatory responses and fever. Its production and activation are regulated processes, not simply an on/off consequence of having a common SNP.

IL5 encodes interleukin-5, a cytokine important to eosinophil growth, survival and activation. Eosinophils are involved in selected allergic and other inflammatory conditions.

Explore folate, vitamin B9, one-carbon metabolism, anemia, homocysteine, SLC19A1, and differences between folate forms and transport pathways.

Explore skin-barrier symptoms, acantholysis, cytokine networks, and redox management.

Explore motor and vocal tics, brain circuits, dopamine, GABA, histamine pathways, behavioral therapies, and treatment and outlook.

Dr. Purser’s subscriber report on IL-5, cytokine genetics, and the topics discussed in his homozygous IL5 variant report.

Explore interleukin-18, caspase-1, the NLRP3 inflammasome, interferon-gamma, and related immune pathways.

Explore rs2910397, rs2637125, steroid sulfation, DHEA, DHEAS, bile acids, and hormone and liver pathways.

And Why Your Methylation, Homocysteine, and Glutathione Pathways Are the Missing Link

A sudden spike in folate or homocysteine is rarely caused by supplements. It is most often the result of a hidden infection or minor injury triggering a cytokine surge. Identifying and treating the underlying source is the key to bringing l

Excerpt from my newest Substack post about ZINC! You don't want to miss this one. "Zinc is an essential trace mineral that plays a pivotal role in numerous biochemical pathways, affecting everything from immune function to hair health. Wh