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What’s searchable?…erferons and other immune signals in lupus. Understand the connection Lupus is an autoimmune condition that can affect several organs. Disease activity is assessed through symptoms, examination, and multiple tests. Follow the pathway Dr. …
This inflammatory condition affects the esophagus. Understand the connection Eosinophilic esophagitis, or EoE, is an inflammatory condition affecting the esophagus. It can cause swallowing difficulty or food to become stuck. Follow the pa…
…neralization. Also called: Vitamin D A nutrient level and a receptor gene answer different questions Dr. Purser places vitamin D in immune, hormone and bone-related teaching. The conversion-genetics chapter includes VDR, which concerns the …
IL6 encodes interleukin-6, a cytokine involved in immune responses and acute-phase signaling. It can appear in discussions of infection, chronic inflammation and metabolic health, with effects that depend on the context. Also called: IL-6, …
IL17A encodes interleukin-17A, a cytokine involved in defense at tissue barriers and inflammatory signaling. It belongs to the Th17 pathway, which is supported by signals including IL-23. Also called: Th17 signaling and persistent inflamma…
TNFSF10 encodes TRAIL, a signaling protein involved in regulated cell death through particular receptors. It is a different member of the TNF-related signaling family from TNF itself. Also called: TRAIL and regulated cell death TNFSF10 enc…
…d oxidase activator (DAOA / G72), rs2391191, D-serine, NMDA receptors, glutamate signaling, and research questions about brain and mood. Understand the connection DAOA, also called G72, is discussed in relation to D-amino acid oxidase, D-s…
…e IL-23/IL-17 axis, and liver inflammation. Understand the connection Dr. Purser explores IL-23 and Th17 signaling in fatty liver disease and inflammatory liver conditions. Older terms NAFLD and NASH appear alongside the newer terms MASLD …
…, and immune-cell recruitment into tissues. Understand the connection CCL2, also called MCP-1, helps recruit monocytes through the CCR2 receptor. Monocytes can become macrophages, cells that remove debris and participate in inflammation. …
…antibody class switching, and autoimmunity. Understand the connection CD40 is a receptor involved in communication between immune cells. Its partner, CD40L, helps activated T cells communicate with B cells and other cells that present mate…
…ar helper T cells, and lymphoid structures. Understand the connection CXCL13, also called BCA-1, helps guide B cells toward organized immune structures. It works through the receptor CXCR5. Follow the pathway Dr. Purser explains how CXCL1…
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