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A subscriber post from Purser Wellness on Substack, covering cytokines and immune signaling, inflammation and antioxidants.

This test result is bad and could indicate an infection, especially viral. This is a great test for those with A1298C and especially who are Homozygous A1298C. Neopterin is bad while biopterin is good. If neopterin is repeatedly high, the BH4 is low. Neopterin is a sensitive marker of cellular mediated immunity. Reduced levels reflect cellular immunity weakening. Increased neopterin occur with infectious, inflammatory, immune system dysfunction or neoplastic disease evolution. Excessive neopterin negatively impacts the Nitric Oxide pathway in the body (e.g. excessive peroxynitrite formation an

…ne is part of the body’s antioxidant network. Monocytes are immune cells that can release cytokines when they receive stress or danger signals. Follow the pathway Dr. Purser discusses reactive oxygen species, NF-κB, NLRP3, and the cytokine…

… stress, and the kidney’s filtering structures. He connects immune signaling with reactive oxygen species and antioxidant defenses while keeping these mechanisms distinct from a confirmed cause of kidney failure. Bring these questions to y…

Learn about the interferon and IL-15 pathways described in this teaching.

If you’ve been struggling with severe chronic fatigue, unexplained anxiety, or cardiovascular red flags, your genes might be trying to tell you something. Millions of patients walk out of traditional clinics with normal blood tests, only to be told their crippling symptoms are "all in their head." If you carry the C677T variant, you aren't crazy—you are dealing with a breakdown in cellular biochemistry. The Problem With Synthetic Folic Acid The standard advice from standard doctors is to take synthetic folic acid. For someone with the C677T genetic mutation, this is disastrous. Your enzyme pat

Your local doctor will likely tell you that MTHFR testing and taking an MTHFR Daily supplement is a waste of money. They might even claim it isn't a real medical issue. After 15 years of hearing this pap, I can tell you they are flat-out wrong . Every day that I run into abject medical ignorance—where medicine arrogantly refuses to bend to the hard truth of proven science—I remember Ignaz Semmelweis. Semmelweis died a broken pauper in an asylum, his life destroyed by the conventional doctors of his generation who refused to accept handwashing. Their dismissive attitude today stems not from mal

…red or stressed cells, it can act as a danger signal to the immune system. Follow the pathway Dr. Purser explains the connection between HMGB1, receptors such as RAGE and TLR4, NF-κB signaling, and ongoing tissue inflammation. He also disc…

Reminder to check out this post about the connections of MTHFR and Fibromyalgia. I like referring to fibromyalgia as a Copper Overload as that's what's really causing many of the issues. https://danpursermd.substack.com/p/cause-or-effect-

WHAT DOES A defective MTHFR gene structure do to you? 1. It causes a reduction in the production of the critical MTHFR enzyme, causing methylation to occur at only 40% of a healthy body’s capacity, or even as much as 70% of its capacity

WHAT DOES A defective MTHFR gene structure do to you? 1. It causes a reduction in the production of the critical MTHFR enzyme, causing methylation to occur at only 40% of a healthy body’s capacity, or even as much as 70% of its capacity

Chapter 1: Homocysteine- A Historical and Clinical Perspective Homocysteine: how the story developed Why this matters Understand why homocysteine became a health topic and why lowering a blood number is not the same as preventing disease.…