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Health BlogMar 13, 2026
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Most people have never heard of homocysteine , yet this small molecule may hold the key to understanding inflammation, cardiovascular disease, neurological problems, and many chronic conditions. For decades, homocysteine was viewed as a toxic substance in the blood. Doctors were taught that lowering it with B-vitamins might reduce heart disease risk. But research results were inconsistent, leaving many physicians unsure whether homocysteine truly mattered. New research and clinical observations are changing that view. We introduce a new framework called the Purser Model , which explains why ho

Gene referenceSep 23, 2026
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IL6 encodes interleukin-6, a cytokine involved in immune responses and acute-phase signaling. It can appear in discussions of infection, chronic inflammation and metabolic health, with effects that depend on the context.

Gene referenceSep 23, 2026
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CXCL13 is a chemokine that attracts cells expressing CXCR5, including B cells. This pairing helps organize immune-cell traffic in lymphoid tissues and some chronic inflammatory settings.

Gene referenceSep 23, 2026
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…ng the pieces together Dr. Purser discusses this pathway in chronic inflammatory settings, including his sickle-cell teaching. IL17A, IL23A and IL23R represent different parts of the same network: a downstream signal, an upstream cytokine c…

Health BlogSep 18, 2026
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…y to reason deeply. The Reality of MTHFR, Homocysteine, and Cytokines These physicians know almost zero about methylation or the FDA and HHS-approved intracellular micronutrient testing we use with our patients. (Yes, targeted vitamin defic…

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