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…n change over time and with stress or other circumstances. Follow the pathway Dr. Purser discusses cortico-striatal-thalamo-cortical circuits, dopamine, and inhibitory GABA signaling. He also explores behavioral therapy, medicines, and sel…

…uch as C677T and A1298C can influence folate metabolism and methylation. Stop blaming yourself. Start understanding the biology. Support your nutrition. Support methylation when appropriate. Prioritize protein, fiber, and healthy fa…

… you LIVE tomorrow. September 5th | 9:00 AM Mountain Time Follow Dan Purser MD and join us LIVE!

… involved in allergies and defense against some parasites. Follow the pathway Dr. Purser connects eosinophil recruitment with allergic airway and skin inflammation. He also discusses research on CCL11 and brain aging; a research associatio…

…an attract monocytes, eosinophils, and other immune cells. Follow the pathway Dr. Purser explains how repeated immune-cell recruitment can sustain tissue inflammation. His teaching connects this pathway with allergic inflammation and discu…

… cells that remove debris and participate in inflammation. Follow the pathway Dr. Purser follows the CCL2–CCR2 pathway through blood-vessel, kidney, and metabolic inflammation. He discusses homocysteine, NF-κB signaling, and reactive oxyge…

…ir; persistent recruitment can contribute to inflammation. Follow the pathway Dr. Purser discusses macrophage activity, osteoclasts that break down bone, and inflammatory joint damage. His teaching also connects CCL3 signaling with oxidati…

… to CCL3, but the two signals do not have identical roles. Follow the pathway Dr. Purser connects CCL4 with T-cell and macrophage recruitment and the way local inflammation can continue after the initial trigger. He discusses oxidative str…

…tes in the normal response to infection and tissue injury. Follow the pathway Dr. Purser discusses CCL5 in chronic inflammatory and immune conditions, including research on nervous-system inflammation. A raised level can have several expla…

…ears on cell surfaces and also circulates as soluble CD14. Follow the pathway Dr. Purser explains how CD14 works with MD-2 and TLR4 to activate inflammatory signals such as NF-κB. This connects bacterial exposure, gut-barrier questions, mo…

…nd other cells that present material to the immune system. Follow the pathway Dr. Purser follows CD40–CD40L signaling into antibody responses, immune activation, and inflammation. He discusses the difference between a useful short-lived re…

…ed immune structures. It works through the receptor CXCR5. Follow the pathway Dr. Purser explains how CXCL13 and CXCR5 help B cells and follicular helper T cells meet in lymph-node germinal centers. He connects ongoing activity in this pat…