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A subscriber post from Purser Wellness on Substack, covering cytokines and immune signaling.

A subscriber post from Purser Wellness on Substack, covering cytokines and immune signaling.

…matory settings, including his sickle-cell teaching. IL17A, IL23A and IL23R represent different parts of the same network: a downstream signal, an upstream cytokine component and a receptor. Their variants do not diagnose an inflammatory di…

…n, and testing. Follow the pathway Dr. Purser explains TNF-alpha, IL-12, IL-23, Th1/Th17 responses, and oxidative stress in the intestinal lining. He discusses the difference between targeting a specific inflammatory pathway and addressing…

…nd often called CSE, breaks down cystathionine to cysteine, alpha-ketobutyrate and ammonia. It also uses PLP. Cysteine can be used in proteins and glutathione production or enter other sulfur-metabolism routes. Other sulfur routes Taurine,…

…Also called: GABP1, GA Binding Protein Transcription Factor Subunit Alpha Start here GABPA is a gene involved in controlling how other genes are used. You may see the label GABP1 in older materials; check the exact variant on your own repor…

… groups immune discussions around signals such as IL-6, TNF-alpha, IL-1 beta, IL-17, IL-23, and interferons. CCL2/MCP-1 and IL-8/CXCL8 are chemokines; CD14 and TLR4 help recognize triggers. DDAH1, RAD50, and clotting factors are not all cyt…

— A Guide by the World’s Leading Homocysteine Expert For more than four decades as a practicing physician, I have watched thousands of patients cycle through conventional autoimmune treatments that address symptoms but never touch the fire underneath. Rheumatoid arthritis flares, lupus rashes, multiple sclerosis relapses, Hashimoto’s thyroiditis, fibromyalgia pain—these are not random. They share a common, often overlooked biochemical pathway: MTHFR mutations leading to elevated homocysteine that supercharges autoimmune inflammation . This is not fringe theory. It is the clinical reality I hav

Dupilumab, sold as Dupixent, is a prescribed antibody medicine that acts on IL-4 receptor alpha.

Infliximab, sold as Remicade and as biosimilars, is a prescribed antibody medicine that targets TNF-alpha.

Follow the IL-23 and IL-17 conversation in Dr. Purser’s psoriasis report.

One member of the vitamin E family; it is distinct from alpha-tocopherol, the form used to establish vitamin E requirements.