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A subscriber post from Purser Wellness on Substack, covering cytokines and immune signaling.

CCL4 encodes MIP-1 beta, a chemokine involved in attracting immune cells. It participates in a recruitment network that includes CCL2, CXCL8 and related chemokines.

Most people have never heard of homocysteine , yet this small molecule may hold the key to understanding inflammation, cardiovascular disease, neurological problems, and many chronic conditions. For decades, homocysteine was viewed as a toxic substance in the blood. Doctors were taught that lowering it with B-vitamins might reduce heart disease risk. But research results were inconsistent, leaving many physicians unsure whether homocysteine truly mattered. New research and clinical observations are changing that view. We introduce a new framework called the Purser Model , which explains why ho

…(with a high homocysteine the cytokines created are IL8 and MCP1). Cytokines are these little proteins in our body that in microscopic amounts clear out old senescent cells). But with homocysteine genetics these are massively over-produced …

A molecule made from glutamate, cysteine and glycine that participates in cellular redox balance.

— A Guide by the World’s Leading Homocysteine Expert For more than four decades as a practicing physician, I have watched thousands of patients cycle through conventional autoimmune treatments that address symptoms but never touch the fire underneath. Rheumatoid arthritis flares, lupus rashes, multiple sclerosis relapses, Hashimoto’s thyroiditis, fibromyalgia pain—these are not random. They share a common, often overlooked biochemical pathway: MTHFR mutations leading to elevated homocysteine that supercharges autoimmune inflammation . This is not fringe theory. It is the clinical reality I hav

VARS Glutathione Capsules – Real Protection, Real Results Most glutathione supplements fail—they’re either oxidized (inactive) or broken down before they can be absorbed. That’s why we created VARS Glutathione Capsules: a patented, validat

Compare studies of homocysteine and glutathione with evidence of benefit in people.

Separate questions about toxin exposure from questions about genetics and antioxidant pathways.

Explore why glutathione is studied in kidney disease without assuming a product improves kidney function.

Follow the questions linking symptoms, genetics, homocysteine, and immune signals.