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YouTube·YouTube publication: Aug 4, 2025

Two sides of the same coin, glutathione and homocysteine and in a very particular balance.

Inflammation
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Original sourceDan Purser MD on YouTube

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0:02

Glutathione and its relationship with homocyine. You may have heard Dr. Perer discuss homocyine extensively lately as he's getting ready to come out with a couple books and some other content on it. But what is the relationship between glutathione and homocyine? Dr. Perers has always explained it as two sides of

0:18

the same coin regulated by the transuleration pathway. Now this may sound a little complicated but really it has to do with our methylation and the way that our body processes methionine all the way into glutathione. So methionine becomes homocyine homoyine

0:34

becomes becomes cysteine and acetylcysteine and knack and acetylcysteine becomes glutathione. In this way they are perfectly related. So glutathione is the direct downstream of homocyine. Now if you have any genetic snips around homocyine that

0:51

causes an a drastic increase of homocyine you will have a major decrease in glutathione levels. This is what causes all kinds of inflammation and cardiovascular and kidney issues because glutathione is not present in the levels

1:07

that it needs to be. This is why we created bars glutathione is to help regulate and balance those homoyine levels. If we can't lower your homoyine levels other than doing drastic low methionine diets which cause all kinds

1:24

of other issues but we can stabilize the homocyine that's already there. Mainly we're trying to stabilize the effects of high homoyine. Primarily the rise of cytoines such as IL8 and MCP-1 by supplementing with reduced glutathione. You can normalize

1:41

and lower these cytoines from raising which then lowers inflammation. You have to think about everything in the body as a call and response or everything has a an an a reaction to an action. If your body is unable to process homocyine or

1:59

if your body is processing too much homocyine creating too much homoyine then it's going to have the downstream effect of not enough glutathione. If you can supplement with high levels of glutathione, reduce glutathione, then your body normalizes on the homocyine

2:15

production and on the cytoine production, everything has its colon response back and forth. And that's all we're trying to do is bring balance. Create that homeostasis that your body is always trying to get to. So utilize your glutathione to help normalize your homoyine levels and cytoine levels and

2:32

watch your inflammation, watch your cardiovascular issues start to dwindle.

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Homocysteine and methylation→Cysteine→L-Methionine→

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Glutathione, from the beginning

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Meet your antioxidant network

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Homocysteine: follow the connections

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Two sides of the same coin, glutathione and homocysteine and in a very particular balance. — Purser Wellness Explore