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YouTube·YouTube publication: Jun 30, 2025

If you have a COMT mutation, your body may not break down estrogen or absorb B12 properly. 😵‍💫

HormonesGenetics
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Original sourceDan Purser MD on YouTube

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YouTube captions · Unreviewed · Imported 2026-09-23

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0:02

How to supplement for the CompTI genetic air? What do you recommend? You should. It pushes you your estradolon to poor breakdown products that are breast inflammatory. So, you would want to take dim I like the design dimmale. Uh but also uh you need to you can't absorb B12

0:18

correctly. Uh and so or you have problems with it, you need extra B12. And I usually use um the pure encapsulations, the Denisyl hydroxy B12 off Amazon. You start with the drops if you're worried about it, but um most people just start with the capsules.

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COMT→Vitamin B12 (Cobalamin)→

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Methylation & B vitamins

Mentions b12 in the captions.

Genetics topicWatch at 0:02 ↗
Menopause & estrogen questions

Mentions estrogen.

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A term in this discussion

PURSER WELLNESSVitamin B12 (Cobalamin)From the reading room
Nutrient referenceSep 23, 2026

Vitamin B12 (Cobalamin)

Needed for nerve function, DNA production and healthy red blood cells.

Testing

A term in this discussion

PURSER WELLNESSCOMTFrom the reading room
Gene referenceSep 23, 2026

COMT

Makes an enzyme that helps break down catechol compounds, including some neurotransmitters. A common variant does not by itself explain mood, attention or stress tolerance.

Genetics

More on Menopause & estrogen questions

PURSER WELLNESSIf you have a COMT mutation, your body may not break down estrogen or absorb B12 properly. 😵‍💫 The fix? Add DIM…A conversation with Dr. Purser
InstagramJun 30, 2025

If you have a COMT mutation, your body may not break down estrogen or absorb B12 properly. 😵‍💫 The fix? Add DIM…

If you have a COMT mutation, your body may not break down estrogen or absorb B12 properly. 😵‍💫 The fix? Add DIM (like DIM Avail) for estrogen balance and use adenosyl + hydroxy B12 for better absorption. Start with drops or go straight to c

Hormones

More on Menopause & estrogen questions

PURSER WELLNESSESR1From the reading room
Gene referenceSep 17, 2026

ESR1

ESR1 is the gene symbol used for Estrogen Receptor 1. This page connects its terminology with the topics in the Purser Wellness teaching library.

Genetics
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If you have a COMT mutation, your body may not break down estrogen or absorb B12 properly. 😵‍💫 — Purser Wellness Explore