Skip to content
Back to the library
YouTube·YouTube publication: Jul 29, 2025

Got MTHFR? The real damage it causes isn’t just genetic—it’s intracellular vitamin deficiencies.

GeneticsTesting
Open on YouTube
From the original video description

Original sourceDan Purser MD on YouTube

Read the conversation.

YouTube captions · Unreviewed · Imported 2026-09-23

Captions can mishear medical terms, names, and doses. Check the recording for context. Each timestamp opens that moment on YouTube.

6 timestamped passages

0:01

If you've been tested and already know you have MTG4, how do you know where to start? Get in or vitamin testing. I really don't care what genetic issues you have. Well, I kind of do it, but I mean, you'll care more than I do, obviously. But my job is to get you feeling normal. And those vitamin deficiencies show up in one major way. Usually, it's it

0:17

sorry, those genetic snips show up in one major way. I already gave it away. It's vitamin deficiencies. Interested deficiencies. N 99% of them are caused by genetic snips. That's how they damage you. That's how they caused you problems. That's how your ancestors died

0:33

early because they got horribly malnourished and died from that genetic stuff. So, say they can't get vitamin testing right now, would it be okay to start on like MTHR renew or MTH? Yeah, if they think they have it. Yeah. Yeah. Like if they know they have MTHR, then those and so if you have like like I saw a lady this week with 29 SNIPS. Oh, good

0:50

lord. That broke her record. um she need like two or three are new and like seven to 10 endure a day a day to read that many. That's ridiculous, but it's the way it is. If you want to feel normal and if you um if you have like 13 or 14 uh like your mom had um you need she

1:08

took one or two Renew and five or six endure for years. Now she's on like four endure. She finally cut got rid of the Renew. I'm on one endure. Yeah. Mhm. It works and people vary. Yeah, that's exactly the point. It takes time. Yeah. Yeah. Cuz you're compound hetererozygous, right?

1:24

I think so. Yeah. And I'm 71. So I take half of a tiny vine, which is a fourth of an in what I take. But but no, taking it felt horrible.

PURSER WELLNESS · PRACTICE & SHOP

Explore your next step.

PHYSICIAN DESIGNEDMTHFR DailyProduct information & ingredientsView productTESTING & CONSULTATIONGenetic testing + consultationExplore the available testing bundlesExplore testing

Product and testing details from our practice and shop. Discuss what fits your needs with your clinician. Current labels, availability and pricing are shown on the linked pages.

ONE MORE CONNECTION MADE

Keep your curiosity going.

A LITTLE CLARITY

Understand the terms

Open a short reference guide.

MTHFR→

FOLLOW YOUR CURIOSITY

Go deeper into this discussion

Genetic testing, one term at a time

Mentions genetic in the captions.

Genetics topicWatch at 0:01 ↗
Your MTHFR starting point

Mentions mthfr.

Genetics topic
Make sense of your testing

Mentions intracellular.

Testing topic

Connections follow subject mentions. Read or watch the source for context.

FOLLOW THE THREAD

Genetics & methylation

Make sense of the vocabulary. Explore MTHFR, genetic variants, and the conversations around methylation.

Explore this topic
A note on the archive

These are the original author’s words and perspectives. Older material may reflect earlier teaching. Use the source and publication date for context.

MORE FROM PURSER WELLNESS

Genetic testing + consultationExplore your inherited patterns.
Physician DesignedMeet the products behind the teaching.
CMA testing + consultationExplore intracellular nutrient testing.

Keep following the thread.

More to explore

A term in this discussion

PURSER WELLNESSMTHFRFrom the reading room
Gene referenceSep 23, 2026

MTHFR

Makes an enzyme that helps produce a form of folate used in the processing of homocysteine. Common variants are different from rare variants that cause severe MTHFR deficiency.

Genetics

More on Genetic testing, one term at a time

PURSER WELLNESSDan Purser MD - Live Q&A and Round Up!A conversation with Dr. Purser
YouTubeSep 6, 2026

Dan Purser MD - Live Q&A and Round Up!

Come chat with Dan Purser MD and Jackson Larkin about all things Purser Wellness - Catch up on new testing, products, books, and MORE!

Wellness

More on Your MTHFR starting point

PURSER WELLNESSMTHFR and the Never-Ending Sugar Crash Cycle: Why You’re Tired, Craving Sugar, and Chasing Energy AA conversation with Dr. Purser
YouTubeAug 29, 2026

MTHFR and the Never-Ending Sugar Crash Cycle: Why You’re Tired, Craving Sugar, and Chasing Energy A

That afternoon sugar craving may be telling you more than you think. Here’s how methylation, glucose, cellular energy and your genetics may fit into the bigger picture. https://danpursermd.substack.com/p/mthfr-and-the-never-ending-sugar?utm_source=youtube

Genetics

More on Your MTHFR starting point

PURSER WELLNESSMTHFR & The Never-Ending Sugar Crash Cycle: Why You’re Always Tired & Craving SweetsA conversation with Dr. Purser
YouTubeJul 19, 2026

MTHFR & The Never-Ending Sugar Crash Cycle: Why You’re Always Tired & Craving Sweets

MTHFR & The Never-Ending Sugar Crash Cycle: Why You’re Always Tired & Craving Sweets If you have an MTHFR variant (C677T or A1298C), you may constantly battle fatigue, sugar cravings, and energy crashes — even when you’re “doing everything right.” In this video, we break down exactly why this happens: How MTHFR/methylation issues impair ATP (energy) production at the cellular level Why your body desperately reaches for quick glucose The vicious cycle of blood sugar spikes → insulin crashes → more cravings & fat storage The downstream effects on antioxidants, DNA repair, and overall energy How to finally break the cycle: Targeted supplementation that fills methylation “holes” (what we learned from 15–20k intracellular tests) Why our MTHFR Daily multivitamin was specifically formulated for this The power of CMA intracellular testing Intermittent fasting (12–16 hrs) Fasted cardio (even just a brisk walk) High-protein, real-food diet with minimal processed sugars If you’re tired of the sugar rollercoaster and want stable energy, this is for you. Links: Read the full Substack article → https://danpursermd.substack.com/p/the-mthfrsugar-craving-cycle Get your CMA intracellular testing & genetics done → Call our office or visit danpursermd.com Shop MTHFR Daily → https://physiciandesigned.com/products/mthfr-daily Have an MTHFR variant? Drop your genotype (heterozygous/homozygous) in the comments — I’m always curious! #MTHFR #SugarCravings #Methylation #ChronicFatigue #Energy #PurserWellness #FunctionalMedicine #IntermittentFasting Follow Dr. Purser! Info: http://www.DanPurserMD.com Supplements: https://www.PhysicianDesigned.com Books: https://www.amazon.com/-/e/B00BIKSGVQ Facebook: https://www.facebook.com/danpursermd Facebook: https://www.facebook.com/PhysicianDesigned Twitter: https://twitter.com/realdanpursermd YouTube: https://www.youtube.com/danpursermd Instagram: https://www.instagram.com/danpurser.md Pinterest: https://www.pinterest.com/danpursermd

Genetics
Purser Wellnessexplore

Good questions open new doors.

Dan Purser MD Physician Designed YouTube Substack Find My PathwayCoursesNutrients & foodsGenes & pathwaysBooks & chaptersAbout this library
© 2026 Purser Wellness

For education. The archive includes clinical perspectives and historical material; it does not replace individual medical care.

Sources & coverageAbout the teachingPrivacyContact & help
Purser Wellnessexplore
DiscoverTopicsCoursesWatchReadAsk Purser
My learning
Got MTHFR? The real damage it causes isn’t just genetic—it’s intracellular vitamin deficiencies. — Purser Wellness Explore