Three different kinds of information deserve three different questions.
Updated September 17, 2026 · Educational reference
Genetics: inherited information
Genetic testing identifies variants. It does not measure a current vitamin level or prove that a symptom comes from a pathway.
CMA: understand the method
The Purser materials discuss cellular micronutrient analysis as a way to explore nutrient-related cell responses. Ask what the assay directly measures, its limitations and whether an abnormality has an established treatment implication.
Blood tests: a clinical snapshot
Blood results depend on the analyte, timing, medicines and clinical context. Compare them with the laboratory’s own range and established clinical guidance.
Putting them together
The Purser teaching approach considers patterns across history and tests. A proposed connection is not independent proof of a diagnosis; ask what additional evidence would change care.
Product and testing details from our practice and shop. Discuss what fits your needs with your clinician. Current labels, availability and pricing are shown on the linked pages.
Sources & perspective
This is an editorial adaptation of the Purser Wellness Method manuscript, practitioner course and testing education materials. Purser teaching connections are labeled separately from clinical interpretation. Private cases and individual treatment protocols are not reproduced.
Use the public resources below for additional context.
If you’ve had our Cellular Micronutrient Assay (CMA) with Redox testing, chances are you’ve looked at those two pages of results and thought, “Okay... now what does all this actually mean?” You’re not alone. This is one of the questions I hear most often from patients.
Let me walk you through exactly what each page shows, how the test works, and why these results are so powerful for creating a truly personalized plan to help you feel your best.
Intracellular testing, or the CMA Cellular Micronutrient Assay, measures over 100 vitamins, minerals, amino acids, and antioxidants inside your cells—not just in your blood. Unlike serum tests, which show short-term levels, intracellular testing reveals what your cells have been missing over the last 100 days. Low levels can mean weak enzymes, non-functioning proteins, and accelerated aging. By identifying deficiencies and matching them with the correct nutrient forms for your genetics, you can target fatigue, anxiety, depression, and other chronic issues at the root. Get your CMA by calling o
MTHFR & The Never-Ending Sugar Crash Cycle: Why You’re Always Tired & Craving Sweets
If you have an MTHFR variant (C677T or A1298C), you may constantly battle fatigue, sugar cravings, and energy crashes — even when you’re “doing everything right.”
In this video, we break down exactly why this happens:
How MTHFR/methylation issues impair ATP (energy) production at the cellular level
Why your body desperately reaches for quick glucose
The vicious cycle of blood sugar spikes → insulin crashes → more cravings & fat storage
The downstream effects on antioxidants, DNA repair, and overall energy
How to finally break the cycle:
Targeted supplementation that fills methylation “holes” (what we learned from 15–20k intracellular tests)
Why our MTHFR Daily multivitamin was specifically formulated for this
The power of CMA intracellular testing
Intermittent fasting (12–16 hrs)
Fasted cardio (even just a brisk walk)
High-protein, real-food diet with minimal processed sugars
If you’re tired of the sugar rollercoaster and want stable energy, this is for you.
Links:
Read the full Substack article → https://danpursermd.substack.com/p/the-mthfrsugar-craving-cycle
Get your CMA intracellular testing & genetics done → Call our office or visit danpursermd.com
Shop MTHFR Daily → https://physiciandesigned.com/products/mthfr-daily
Have an MTHFR variant? Drop your genotype (heterozygous/homozygous) in the comments — I’m always curious!
#MTHFR #SugarCravings #Methylation #ChronicFatigue #Energy #PurserWellness #FunctionalMedicine #IntermittentFasting
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That afternoon sugar craving may be telling you more than you think. Here’s how methylation, glucose, cellular energy and your genetics may fit into the bigger picture.
https://danpursermd.substack.com/p/mthfr-and-the-never-ending-sugar?utm_source=youtube
