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Explore Toll-like receptor 2, microbial and damage signals, TLR1, TLR6, and MyD88 signaling.

Explore RAD50, the MRE11–RAD50–NBS1 (MRN) complex, DNA double-strand breaks, genomic stability, and related DNA-repair and antioxidant pathways.

Explore the NLRP3 sensor, inflammasome priming and activation, IL-1 beta, IL-18, and pyroptosis.

Explore IL-23, IL-17, TNF-alpha, HLA-B27, spinal inflammation, and treatment questions.

Explore volatile hypertension, autonomic regulation, monocytes, vascular inflammation, and how they may connect.

Dan Purser MD interviews a patient with a brutal sarcoidosis case involving sky-high SIL2R cytokines, GI sarcoid, heart damage, and years of being dismissed by doctors. After spleen removal, repeated ER visits, and nitroglycerin dependence, he finally found answers. Learn how cytokine testing and the VARS Trio (Glutathione + SOD + Catalase) led to rapid improvement — going from bedridden fear to playing with grandkids in just weeks. This episode highlights the power of root-cause medicine for complex inflammatory conditions and offers hope for those who feel lost in the system. Perfect for listeners dealing with sarcoidosis, chronic inflammation, autoimmune issues, or cytokine-related symptoms. #Sarcoidosis #Cytokines #VARS #PurserWellness #ChronicIllnessRecovery Follow Dr. Purser! Info: http://www.DanPurserMD.com Supplements: https://www.PhysicianDesigned.com Books: https://www.amazon.com/-/e/B00BIKSGVQ Facebook: https://www.facebook.com/danpursermd Facebook: https://www.facebook.com/PhysicianDesigned Twitter: https://twitter.com/realdanpursermd YouTube: https://www.youtube.com/danpursermd Instagram: https://www.instagram.com/danpurser.md Pinterest: https://www.pinterest.com/danpursermd

Could the signals controlling your health be working for you... or against you? Most people have never heard of cytokines, yet these powerful cellular messengers play a critical role in how your body responds to stress, inflammation, recov

The Overlooked Link Between MTHFR Mutations, Hyperhomocysteinemia, PCOS, Fibromyalgia, Chronic Inflammation, and Renal Decline — and Why Precision Genetic Testing May Be the Missing Step

The Overlooked Link Between MTHFR Mutations, Hyperhomocysteinemia, PCOS, Fibromyalgia, Chronic Inflammation, and Renal Decline — and Why Precision Genetic Testing May Be the Missing Step https://danpursermd.substack.com/p/can-glutathione-reverse-kidney-disease?utm_source=youtube

A sudden spike in folate or homocysteine is rarely caused by supplements. It is most often the result of a hidden infection or minor injury triggering a cytokine surge. Identifying and treating the underlying source is the key to bringing l

Years ago, I watched cystic fibrosis (CF) patients receive nebulized glutathione that didn’t seem to help. Decades later, our team developed and patented the first fully functional, reduced, and stable form — VARS Glutathione. Why does thi

A post from Purser Wellness on Substack, covering cytokines and immune signaling, inflammation and antioxidants.