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Most people have never heard of homocysteine , yet this small molecule may hold the key to understanding inflammation, cardiovascular disease, neurological problems, and many chronic conditions. For decades, homocysteine was viewed as a toxic substance in the blood. Doctors were taught that lowering it with B-vitamins might reduce heart disease risk. But research results were inconsistent, leaving many physicians unsure whether homocysteine truly mattered. New research and clinical observations are changing that view. We introduce a new framework called the Purser Model , which explains why ho

Kidney disease has many possible causes.

Explore immune signaling in the context of autoimmune thyroid disease.

Dr. Purser discusses interleukins and oxidative stress in cystic fibrosis lung disease.

NOS3 encodes endothelial nitric oxide synthase, which helps blood vessels generate nitric oxide, a signal involved in vascular relaxation. This pathway is distinct from a blood pressure measurement or a diagnosis of vascular disease.

PSEN1 encodes a presenilin protein that participates in gamma-secretase, a protein-processing complex. Some pathogenic variants can cause familial Alzheimer’s disease; a listed common marker is not equivalent to that diagnosis.

PSEN2 encodes a presenilin protein that participates in gamma-secretase, a protein-processing complex. Some pathogenic variants can cause familial Alzheimer’s disease; a listed common marker is not equivalent to that diagnosis.

F9 encodes coagulation factor IX. Disease-causing variants can result in hemophilia B, an inherited bleeding disorder, but a panel marker is not equivalent to a confirmed disease-causing finding.

Homocysteine rarely gets the attention of cholesterol, blood sugar, or blood pressure. It should. When homocysteine becomes elevated, it has been associated with cardiovascular disease, stroke, cognitive decline, blood clots, and other he

🌾 Why has gluten intolerance exploded since the 1970s? It’s not just the bread. In my latest blog I lay out the clear timeline: Roundup (glyphosate) was introduced in 1974… and the rise in celiac disease and gluten sensitivity has tracked

The Hidden Driver of Chronic Disease

CRISPR is in the process of coming up with a treatment to change your genetic mutations. This could mean helping fix the mutations that put you at risk for Alzheimer's disease, macular degeneration, strokes, or Factor V Leiden. Stay on the look out for this very exciting new technology as it advances!