ESR1 encodes estrogen receptor alpha, which helps cells respond to estrogen. Receptor signaling is different from the amount of estrogen measured in blood.
Also called: Estrogen Receptor 1
Estrogen signaling depends on the receptor
ESR1 enc…
Encodes an enzyme involved in fatty-acid metabolism.
Also called: Fatty Acid Desaturase 1 / D5D
The form of a fatty acid matters
Dr. Purser teaches FADS genes as a conversion pathway. FADS1 participates in a delta-5 desaturase step in fatty…
Encodes an enzyme involved in fatty-acid metabolism.
Also called: Fatty Acid Desaturase 2 / D6D
The form of a fatty acid matters
Dr. Purser teaches FADS genes as a conversion pathway. FADS2 participates in a delta-6 desaturase step in fatty…
FOLH1 helps break down folate from food so it can be absorbed. This is different from the MTHFR step.
Also called: Folate Hydrolase 1
Folate handling begins before remethylation
Dr. Purser’s genetic chapters include FOLH1 in folate handling…
FOLR1 encodes folate receptor alpha, which helps cells take up folate and has an important role in folate transport at the brain’s barriers. Blood folate and folate availability in the nervous system are not identical measurements.
Also cal…
FOLR2 encodes folate receptor beta, a folate-binding protein expressed in particular cell types, including subsets of immune cells. It is distinct from the FOLR1 receptor and the SLC19A1 reduced folate carrier.
Also called: Folate Receptor …
FTO is studied in relation to body weight and energy balance. Common variants can contribute to population-level differences in obesity susceptibility, alongside many other genes and environmental factors.
Also called: Fat Mass and Obesity-…
FUT2 affects substances on the surfaces of the gut and other moist tissues and is studied in relation to the microbiome.
Also called: Fucosyltransferase 2
The mucosal and microbiome connection
Dr. Purser’s course places FUT2 in its gut–immu…
G6PC2 encodes a glucose-6-phosphatase-related protein expressed in pancreatic islet cells. Common variation is associated with differences in fasting glucose regulation; it is not the insulin receptor.
Also called: Glucose-6-Phosphatase Cat…
GAD1 helps your body make GABA, a chemical messenger, from glutamate.
Also called: Glutamate Decarboxylase 1
The glutamate-to-GABA connection
Dr. Purser’s course uses GAD/GABA teaching to explain a connection between excitatory and inhibito…
GAD2 helps make GABA, a chemical messenger, from glutamate.
Also called: Glutamate Decarboxylase 2
Another part of the GABA system
GAD2 helps make GABA from glutamate. GAD1 does a related job, but the two genes are different. Check the exac…
GCLC helps make glutathione, an antioxidant your body produces.
Also called: Glutamate-Cysteine Ligase Catalytic Subunit
Making glutathione is a process
Dr. Purser groups GCLC and GCLM as glutathione-synthesis machinery. GCLC supplies the c…
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