AHCY
Some search terms matchedThe genetic-architecture chapter explains that S-adenosylmethionine (SAM) donates methyl groups and becomes S-adenosylhomocysteine (SAH).
Also called: Adenosylhomocysteinase
Methyl-group use leaves another molecule behind
The genetic-archit…
AOC1
Some search terms matchedEncodes diamine oxidase, an enzyme involved in breaking down histamine and other amines. DAO is used here as an enzyme nickname; it is also the official symbol of a different gene.
Also called: DAO, Amine Oxidase, Copper Containing 1, Diami…
APOE
Some search terms matchedAPOE encodes a protein that carries lipids between cells. The familiar APOE e2, e3 and e4 groupings depend on the combination of rs429358 and rs7412, not on either marker read in isolation.
Also called: Apolipoprotein E
Lipid transport and …
ATG16L1
Some search terms matchedATG16L1 is involved in autophagy, a process that helps cells recycle parts.
Also called: Autophagy-Related 16-Like 1
Cellular recycling meets gut immunity
ATG16L1 is involved in autophagy, a process that helps cells recycle parts. It is stu…
BHMT
Some search terms matchedBHMT helps recycle homocysteine into methionine using betaine. It is a different route from the folate and B12 pathway.
Also called: BHMT08, Betaine-Homocysteine S-Methyltransferase
Another route through the homocysteine map
BHMT is part of…
BRCA1
Some search terms matchedBRCA1 helps repair damaged DNA. Clinically classified pathogenic variants can affect inherited cancer risk; a common SNP or a variant of uncertain significance is a different finding.
Also called: Breast Cancer 1
DNA repair and inherited ca…
BRCA2
Some search terms matchedBRCA2 helps repair damaged DNA. Clinically classified pathogenic variants can affect inherited cancer risk; a common SNP or a variant of uncertain significance is a different finding.
Also called: Breast Cancer 2
DNA repair and inherited ca…
CD14
Some search terms matchedCD14 helps immune cells recognize microbial components, including bacterial lipopolysaccharide, as part of innate immune signaling. This places it upstream of some cytokine responses.
Also called: Cluster of Differentiation 14
How immune ce…
CHDH
Some search terms matchedCHDH helps convert choline toward betaine, a nutrient involved in the homocysteine pathway.
Also called: Choline Dehydrogenase
Choline can serve more than one purpose
CHDH helps convert choline toward betaine, while PEMT helps make phosphat…
COL5A1
Some search terms matchedCOL5A1 encodes one component of type V collagen, which helps organize collagen fibers. It connects to the strength and structure of tendons, skin and other connective tissues.
Also called: Collagen Type V Alpha 1 Chain
Collagen structure, t…
COMT
Some search terms matchedMakes an enzyme that helps break down catechol compounds, including some neurotransmitters. A common variant does not by itself explain mood, attention or stress tolerance.
Also called: Catechol-O-Methyltransferase
Catecholamines and sensit…
DHFR
Some search terms matchedDHFR helps reduce folic acid and dihydrofolate to tetrahydrofolate-related forms used in cellular metabolism. This is one part of the folate system, distinct from MTHFR and folate transport into cells.
Also called: Dihydrofolate Reductase
R…
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