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…ammatory processes as well as the cancer cells themselves. Follow the pathway Dr. Purser discusses asbestos-related injury, HMGB1 danger signaling, TNF-alpha, NF-κB, and oxidative stress as research pathways. Understanding an inflammatory …

…quire a combination of symptoms, examination, and testing. Follow the pathway Dr. Purser explains TNF-alpha, IL-12, IL-23, Th1/Th17 responses, and oxidative stress in the intestinal lining. He discusses the difference between targeting a s…

…n be delayed after exposure and may differ between people. Follow the pathway Dr. Purser connects the IgE allergy response with Th2 signaling, including IL-4, IL-5, and IL-13, and with eosinophil-related inflammation. The immune pathway ex…

…mmune-mediated condition that needs a clinical assessment. Follow the pathway Dr. Purser connects immune-cell activity, cytokines, and oxidative stress with gland inflammation. His teaching distinguishes symptom relief for dryness from a d…

…cruit and maintain cells that participate in this process. Follow the pathway Dr. Purser follows the IFN-gamma pathway through CXCL9 and CXCL10, which guide immune cells, and IL-15, which helps sustain memory T cells. He discusses JAK sign…

…help produce the redness, swelling, and pain of an attack. Follow the pathway Dr. Purser follows crystal recognition through NLRP3, caspase-1, and IL-1 beta into inflammatory-cell recruitment. This distinguishes the crystal trigger from th…

…imary and secondary Raynaud’s have different implications. Follow the pathway Dr. Purser connects blood-vessel function, endothelial stress, and inflammatory pathways in secondary Raynaud’s. He discusses the difference between a common cir…

…some therapies work better for particular asthma patterns. Follow the pathway Dr. Purser connects IL-4, IL-5, IL-13, eosinophil activity, and oxidative stress in the airways. He discusses therapies directed at type 2 signaling alongside th…

… connected, but they are not interchangeable measurements. Follow the pathway Dr. Purser discusses Th1 and Th17 signaling, interferons, IL-6, and TNF-alpha alongside thyroid autoantibodies and oxidative stress. Thyroid hormone replacement …

…morning stiffness. Similar symptoms can have other causes. Follow the pathway Dr. Purser focuses on IL-6, innate immune activity, and the distinction between inflammation and the person’s nutrient or antioxidant status. He discusses cortic…

… X chromosome, which changes how inheritance is described. Follow the pathway Dr. Purser discusses the Leyden form of hemophilia B and why the exact variant, chromosome context, and factor IX activity matter. Some Leyden patterns can chang…

…syndrome, which differs from simply carrying a common SNP. Follow the pathway Dr. Purser connects collagen structure with joint laxity, tendon symptoms, skin and wound healing, and autonomic concerns such as POTS. He discusses strength and…