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A compound made in the body that participates in the citric acid cycle and amino-acid metabolism.

BHMT helps recycle homocysteine into methionine using betaine. It is a different route from the folate and B12 pathway.

Makes the methionine synthase enzyme, which uses vitamin B12 in the conversion of homocysteine to methionine.

Helps maintain the activity of methionine synthase, connecting B12-related chemistry with homocysteine metabolism.

Explore hair shedding, the hair-growth cycle, telogen effluvium, nutrient deficiencies, and questions about changes during supplementation.

You eat something sweet. Your energy shoots up. Then suddenly you are exhausted, foggy, irritable, and reaching for something else to get you through the day. That cycle deserves a closer look. MTHFR variants can influence folate meta

Dr. Purser explains the diagnosis and treatment of MTHFR (methylenteterahydrofolate reductase enzyme deficiency disease). Learn the genetic component of this illness (such as C677T or A1298C) and how it affects the body's inability of methylation to convert carbohydrates into ATP (Adenosine Triphosphate). Discover how the complex enzyme pathways of the Krebs cycle and citric acid cycle convert carbohydrate molecules into ATP molecules in the mitochondria. Explore the relationship of MTHFR to vitamin and hormone deficiencies while understanding how vitamin supplements can replace key missing (u

TMG (trimethylglycine) can sometimes lower homocysteine—but only if it’s not caused by genetics. When homocysteine is high from genetic SNPs, TMG won’t fix it, and restrictive “low-methionine diets” are both harmful and outdated. The real s

TMG (trimethylglycine) can sometimes lower homocysteine—but only if it’s not caused by genetics. When homocysteine is high from genetic SNPs, TMG won’t fix it, and restrictive “low-methionine diets” are both harmful and outdated. The real solution lies in addressing deficiencies and genetics directly. Follow Dr. Purser! Info: http://www.DanPurserMD.com Supplements: https://www.PhysicianDesigned.com Books: https://www.amazon.com/-/e/B00BIKSGVQ Facebook: https://www.facebook.com/danpursermd Facebook: https://www.facebook.com/PhysicianDesigned Twitter: https://twitter.com/realdanpursermd YouTube: https://www.youtube.com/danpursermd Instagram: https://www.instagram.com/danpurser.md Pinterest: https://www.pinterest.com/danpursermd

🚨 High homocysteine isn’t just a lab number—it’s a warning sign. Genes like MTHFR, MTR, MTRR, and GGH can overactivate the methylation cycle and lead to hyperhomocysteinemia, which drives inflammation, stroke risk, and even kidney failure.

If your transsulfuration pathway is off, it’s not just genetics—deficiencies in B6, glutathione, glycine, serine, glutamine, or methionine can block it too. 🧬 Without these, you can’t convert homocysteine to glutathione, leading to inflamma

If you have MTHFR gene mutations like C677T or A1298C, you’re likely low in more than just B12 and folate. 🧬 We consistently see deficiencies in B6 (pyridoxine), glutamine, glutathione, and sometimes methionine—all key players in energy, de