Let’s explore “Cytokines”

A subscriber post from Purser Wellness on Substack, covering cytokines and immune signaling, inflammation and antioxidants.

A subscriber post from Purser Wellness on Substack, covering cytokines and immune signaling.

A subscriber post from Purser Wellness on Substack, covering cytokines and immune signaling, inflammation and antioxidants.

PURSER WELLNESSThe Hidden Molecule Driving Inflammation: Understanding the Purser Model of HomocysteineFrom the reading room

…mage. Instead, it acts as a marker of cytokine sensitivity. Cytokines are inflammatory signaling molecules released by immune cells. When homocysteine rises, it can trigger immune cells—especially monocytes and endothelial cells—to release …

PURSER WELLNESSMTHFR Mutations, Elevated Homocysteine & Autoimmune Inflammation: The Hidden Root Cause Most Doctors MissFrom the reading room

…homocysteine, and a body-wide amplification of inflammatory cytokines. Homocysteine is not merely a cardiovascular marker. It is a potent “cytokine amplifier.” When levels climb above 10–12 µmol/L (my functional optimum is <7–8 µmol/L), hom…

PURSER WELLNESSHow To Know If You Have High Homocysteine?A conversation with Dr. Purser

…eted B vitamins (like MTHFR Daily) are key to balancing the cytokines and deficiencies that come with it.

Dr. Purser’s subscriber report on IL-5, cytokine genetics, and the topics discussed in his homozygous IL5 variant report.

Dr. Purser’s subscriber report on IL-10 dysregulation, immune signaling, and his discussion of the VARS Antioxidant Triad.

Dr. Purser’s subscriber report on IL-17, homozygosity, and the skin, joint, and digestive topics raised in the public introduction.

By Dan Purser MD Pathway-level clinical interpretation focused on inflammatory interaction, likely signs, and likely complications

Why elevated soluble IL-2 receptor levels drive chronic inflammation and pain in sarcoidosis — and what actually helps quiet the fire

The Overlooked Link Between MTHFR Mutations, Hyperhomocysteinemia, PCOS, Fibromyalgia, Chronic Inflammation, and Renal Decline — and Why Precision Genetic Testing May Be the Missing Step