Let’s explore “HOMA-IR — lab reference”

PURSER WELLNESSThe Hidden Molecule Driving Inflammation: Understanding the Purser Model of HomocysteineFrom the reading room

…lly recycles it through several metabolic pathways that require nutrients like: Vitamin B6 Vitamin B12 Folate Serine Glutathione When those pathways work properly, homocysteine stays in balance. But when the system becomes disrupted—because…

…y oxygen and supports many cellular processes. Also called: Iron Energy is not enough reason to add iron Dr. Purser’s course connects iron with oxygen transport and energy while identifying it as a safety-sensitive mineral. This makes it di…

…y fat sources fit this pathway? Variant IDs in the teaching reference: rs1501299, rs2241766, rs266729

…individual clinical discussion. Variant IDs in the teaching reference: rs819147

…ing it, responding to it, clearing it Dr. Purser’s genetics reference places AOC1 in the histamine-clearance part of the gut and immune story. The enzyme it encodes, diamine oxidase, helps break down histamine and related amines. That is a …

…e health factors matter for me? Variant IDs in the teaching reference: rs429358, rs7412

…the same conversation. Those connections do not make an IBS label, Crohn’s disease or another diagnosis interchangeable, and a common variant is not a substitute for a digestive workup. A question to bring to your visit Which part of my his…

…ore using preformed vitamin A, which can accumulate and requires particular care during pregnancy. A question to bring to your visit Am I relying mainly on beta-carotene, and is there evidence of a vitamin A problem? Variant IDs in the teac…

…why Dr. Purser looks at several pathways together: the same laboratory marker can sit at the intersection of more than one nutrient-dependent process. The presence of a variant is not, by itself, a reason to add betaine. A question to bring…

BRCA1 helps repair damaged DNA. Clinically classified pathogenic variants can affect inherited cancer risk; a common SNP or a variant of uncertain significance is a different finding. Also called: Breast Cancer 1 DNA repair and inherited ca…

BRCA2 helps repair damaged DNA. Clinically classified pathogenic variants can affect inherited cancer risk; a common SNP or a variant of uncertain significance is a different finding. Also called: Breast Cancer 2 DNA repair and inherited ca…

…with glutathione production. In that map, CBS concerns the first step moving homocysteine into the transsulfuration pathway. Cysteine is one of the building blocks used to make glutathione. How Dr. Purser connects the pieces The course dist…