Let’s explore “Transsulfuration: from homocysteine to glutathione”

Jackson Larkin and Lois Schweigert discuss the experience of living with fibromyalgia and the Purser Wellness approach.

…lled: Serine An amino acid with two pathway connections The homocysteine chapters place serine in the transsulfuration discussion, while the practitioner course connects SHMT1 with serine/glycine and folate chemistry. Serine therefore helps…

… called: Glutamate-Cysteine Ligase Catalytic Subunit Making glutathione is a process Dr. Purser groups GCLC and GCLM as glutathione-synthesis machinery. GCLC supplies the catalytic component of the first enzyme step in glutathione synthesis…

…o called: Glutamate-Cysteine Ligase Modifier Subunit Making glutathione is a process Dr. Purser groups GCLC and GCLM as glutathione-synthesis machinery. GCLM supplies the modifier component that helps regulate that same glutathione-synthesi…

GSR encodes glutathione reductase. It uses reducing power from NADPH to help convert oxidized glutathione back to reduced glutathione, allowing this antioxidant system to be reused.

GSTO1 belongs to the omega family of glutathione S-transferases. These enzymes participate in redox chemistry, with roles that differ from the better-known GSTM1 and GSTP1 pathways.

…his inflammatory and tissue-damage teaching and places VARS Glutathione within his redox-support framework. That approach does not replace evaluation of infection, autoimmune disease or another cause of inflammation, and the genotype does n…

GSTO2 encodes glutathione S-transferase omega 2, a redox enzyme with dehydroascorbate reductase activity that connects glutathione chemistry with vitamin C recycling. It is a separate gene from GSTO1.

PURSER WELLNESSGlutathione: The Real Detoxifier #substack #shortsA conversation with Dr. Purser

New public listing. Open the original source for the full discussion.

This report overview covers SERPINE1 / PAI-1, rs1799889, 4G/5G, fibrinolysis, hyperhomocysteinemia (HHcy), vascular health, and the report’s comparisons of approaches to clotting risk.

A fast look at the genetic quirks I came across this week, from odd inherited traits to the ones that can seriously affect health. Clear, curious, and a little alarming.

Homocysteine rarely gets the attention of cholesterol, blood sugar, or blood pressure. It should. When homocysteine becomes elevated, it has been associated with cardiovascular disease, stroke, cognitive decline, blood clots, and other he