Let’s explore “Interleukins”

A subscriber post from Purser Wellness on Substack, covering cytokines and immune signaling, inflammation and antioxidants.

A subscriber post from Purser Wellness on Substack, covering cytokines and immune signaling.

A subscriber post from Purser Wellness on Substack, covering cytokines and immune signaling, inflammation and antioxidants, gut and digestion.

A subscriber post from Purser Wellness on Substack, covering cytokines and immune signaling.

A subscriber post from Purser Wellness on Substack, covering cytokines and immune signaling, inflammation and antioxidants, mind, mood, and sleep.

A subscriber post from Purser Wellness on Substack, covering cytokines and immune signaling.

PURSER WELLNESSMTHFR Mutations, Elevated Homocysteine & Autoimmune Inflammation: The Hidden Root Cause Most Doctors MissFrom the reading room

— A Guide by the World’s Leading Homocysteine Expert For more than four decades as a practicing physician, I have watched thousands of patients cycle through conventional autoimmune treatments that address symptoms but never touch the fire underneath. Rheumatoid arthritis flares, lupus rashes, multiple sclerosis relapses, Hashimoto’s thyroiditis, fibromyalgia pain—these are not random. They share a common, often overlooked biochemical pathway: MTHFR mutations leading to elevated homocysteine that supercharges autoimmune inflammation. This is not fringe theory. It is the clinical reality I have

The Overlooked Link Between MTHFR Mutations, Hyperhomocysteinemia, PCOS, Fibromyalgia, Chronic Inflammation, and Renal Decline — and Why Precision Genetic Testing May Be the Missing Step

PURSER WELLNESSCope with Homocysteine Like a Pro!A conversation with Dr. Purser

High homocysteine signals a broken transsulfuration pathway, leaving you unable to detox or convert it into glutathione. This shows up in conditions like PCOS and fibromyalgia, where patients often struggle with inflammation, pain, and even infertility. Genetics play a big role—there are 17 SNPs that can lock homocysteine in place—but vitamin deficiencies can make it worse. The real breakthrough isn’t lowering homocysteine itself but calming the cytokines it triggers, like IL-8 and MCP-1. That’s why VARS Glutathione, the only patented oral form proven to work, is so powerful—it lowers those cy

PURSER WELLNESSHow To Know If You Have High Homocysteine?A conversation with Dr. Purser

High homocysteine often shows up first as widespread inflammation—pain all over, poor circulation, or even early warning signs of cardiovascular problems like stroke and heart attack. The best way to know for sure is through testing: a blood test can measure homocysteine directly, while a CMA with Redox uncovers the vitamin deficiencies driving it. For genetic causes, the DRP Genetics panel screens 15–16 of the 17 known SNPs that can cause permanently high homocysteine. If your levels are fixed by genetics, reduced glutathione and targeted B vitamins (like MTHFR Daily) are key to balancing the

PURSER WELLNESSWhat Makes A Functional Glutathione?A conversation with Dr. Purser

Most glutathione supplements fail because they break down before your body can use them. VARS Glutathione is different—it’s patented, validated, and proven to raise real intracellular glutathione levels. That means it actually works to calm inflammation, lower cytokines, and protect your cells where it matters most.

PURSER WELLNESSThe Struggle of HomocysteineA conversation with Dr. Purser

High homocysteine? It’s not the number—it’s the cytokines it triggers (like IL-8) that cause strokes, kidney failure & inflammation. We found 17 gene SNPs + 12 vitamin deficiencies that drive it—and VARS Glutathione helps shut it down.