Free T4 — lab reference
In the reference guideBinding abnormalities and severe illness may affect some free-hormone assays.
THE PURSER WELLNESS LIBRARY
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What’s searchable?Binding abnormalities and severe illness may affect some free-hormone assays.
Useful in selected hyperthyroid states; not a sensitive stand-alone test for hypothyroidism.
Affected by thyroid-binding globulin, pregnancy, estrogen, and medications.
Mayo example age 20-24: M 5.25-20.7; F <0.13-1.08. Declines with age and is method-dependent.
Often used when total PSA is in an indeterminate zone. Use the performing-lab risk table.
Supine collection and stress control improve specificity; use exact lab cutoffs.
Lab-specific. Interpret with symptoms, medication effects, and differential.
Altitude, smoking, hydration, androgen therapy, and pregnancy may shift values.
Consider altitude and iron/B12/folate status. Pregnancy requires trimester-specific ranges.
Hydration and altitude are major modifiers. Review alongside hemoglobin and RBC indices.
Macrocytosis and microcytosis require cause-specific interpretation.
Analyzer-specific. Review with MCV and MCHC.
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