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Explore interleukin-15 receptor subunit alpha, IL-15 signaling, natural killer cells, CD8+ T cells, and pain.

Explore interleukin-18 receptor accessory protein, IL18R1, MyD88, and mucosal and systemic inflammation.

Explore the p19 and p40 subunits, interleukin-23, and the difference between the IL23A gene and the IL23R receptor.

Explore Toll-like receptor 2, microbial and damage signals, TLR1, TLR6, and MyD88 signaling.

Explore RAD50, the MRE11–RAD50–NBS1 (MRN) complex, DNA double-strand breaks, genomic stability, and related DNA-repair and antioxidant pathways.

Explore the NLRP3 sensor, inflammasome priming and activation, IL-1 beta, IL-18, and pyroptosis.

Explore IL-23, IL-17, TNF-alpha, HLA-B27, spinal inflammation, and treatment questions.

Explore volatile hypertension, autonomic regulation, monocytes, vascular inflammation, and how they may connect.

The Overlooked Link Between MTHFR Mutations, Hyperhomocysteinemia, PCOS, Fibromyalgia, Chronic Inflammation, and Renal Decline — and Why Precision Genetic Testing May Be the Missing Step

A sudden spike in folate or homocysteine is rarely caused by supplements. It is most often the result of a hidden infection or minor injury triggering a cytokine surge. Identifying and treating the underlying source is the key to bringing l

Years ago, I watched cystic fibrosis (CF) patients receive nebulized glutathione that didn’t seem to help. Decades later, our team developed and patented the first fully functional, reduced, and stable form — VARS Glutathione. Why does thi

A post from Purser Wellness on Substack, covering cytokines and immune signaling, inflammation and antioxidants.