Follow Dr. Purser’s discussion of interferons and other immune signals in lupus.
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What’s searchable?HLA-DQA2 is part of the HLA class II region involved in immune recognition. It should not be treated as interchangeable with HLA-DQA1 or as a measurement of how well the immune system fights infections.
CCL2 encodes MCP-1, a chemokine that attracts monocytes toward sites of immune activity. Recruitment is a different task from the cytokines that activate those cells once they arrive.
CXCR5 encodes the receptor for CXCL13. This receptor helps guide B cells and certain T cells toward locations where organized immune responses develop.
HMGB1 normally has functions inside the cell nucleus. When released outside cells in particular settings, it can act as a damage-associated molecular pattern, or DAMP, participating in inflammatory signaling. Also called: A cellular protei…
IL15 encodes a cytokine involved in the survival and activity of immune cells, including natural killer cells and memory CD8 T cells. Its receptor system includes IL15RA.
IL16 encodes interleukin-16, a cytokine involved in attracting and influencing immune cells, including CD4-expressing cells. Its recruitment role helps separate it from other numbered interleukins.
Explore membrane and soluble CD14, lipopolysaccharide (LPS), TLR4, and innate immune activation.
Explore B-cell attracting chemokine-1, CXCR5, B cells, follicular helper T cells, and lymphoid structures. Understand the connection CXCL13, also called BCA-1, helps guide B cells toward organized immune structures. It works through the re…
Explore interleukin-18, caspase-1, the NLRP3 inflammasome, interferon-gamma, and related immune pathways.
Explore interleukin-2 receptor alpha, regulatory T cells, soluble IL-2 receptor, and T-cell activation. Understand the connection IL2RA encodes CD25, the alpha chain of the IL-2 receptor. It helps cells respond to IL-2 and participates in …
Explore sIL2R, sCD25, soluble interleukin-2 receptor, T-cell activation, and sarcoidosis. Understand the connection Soluble IL-2 receptor, or sIL2R, is a released part of the CD25 receptor and is also called sCD25. Its level can reflect T-…
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