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Follow the IL-23 and IL-17 conversation in Dr. Purser’s psoriasis report.

Learn about the interferon and IL-15 pathways described in this teaching.

Learn how eosinophils and type 2 immune signals are discussed in this teaching.

Follow Dr. Purser’s discussion of folate metabolism and inflammation.

Lichen planus can affect skin, mouth, nails, and other surfaces.

This variant is in a regulatory region of the TNF gene.

This TNF promoter variant appears in Dr. Purser’s discussion of inflammatory signaling.

This inflammatory condition affects the esophagus.

This immune-mediated condition can affect the optic nerves and spinal cord.

Dr. Purser discusses interleukins and oxidative stress in cystic fibrosis lung disease.

If you’ve been struggling with severe chronic fatigue, unexplained anxiety, or cardiovascular red flags, your genes might be trying to tell you something. Millions of patients walk out of traditional clinics with normal blood tests, only to be told their crippling symptoms are "all in their head." If you carry the C677T variant, you aren't crazy—you are dealing with a breakdown in cellular biochemistry. The Problem With Synthetic Folic Acid The standard advice from standard doctors is to take synthetic folic acid. For someone with the C677T genetic mutation, this is disastrous. Your enzyme pat

FOLR2 encodes folate receptor beta, a folate-binding protein expressed in particular cell types, including subsets of immune cells. It is distinct from the FOLR1 receptor and the SLC19A1 reduced folate carrier.