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See how crystals and immune signals play different roles in a gout flare.

Understand the gene and enzyme discussed in Dr. Purser’s DAO report.

Go beyond calcium in Dr. Purser’s discussion of mineral status.

Explore Dr. Purser’s connection between methylation and purine pathways.

What if mold exposure is only part of the story? Two people can share the same environment and have completely different experiences. Why? The answer may involve far more than the mold itself. Glutathione is one of the body's major anti

Helps fluid balance, nerve signaling and muscle contraction.

The genetic-architecture chapter explains that S-adenosylmethionine (SAM) donates methyl groups and becomes S-adenosylhomocysteine (SAH).

ESR1 encodes estrogen receptor alpha, which helps cells respond to estrogen. Receptor signaling is different from the amount of estrogen measured in blood.

FOLR1 encodes folate receptor alpha, which helps cells take up folate and has an important role in folate transport at the brain’s barriers. Blood folate and folate availability in the nervous system are not identical measurements.

GDF5 encodes growth differentiation factor 5, a signaling protein involved in skeletal development, joint formation and cartilage biology. Its name does not mean a SNP measures the ability to build muscle.

GSTO1 belongs to the omega family of glutathione S-transferases. These enzymes participate in redox chemistry, with roles that differ from the better-known GSTM1 and GSTP1 pathways.

HFE helps regulate iron absorption through signaling that influences hepcidin. The commonly discussed C282Y and H63D variants correspond to rs1800562 and rs1799945. Their implications depend on the combination present and clinical findings.