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…cusses cytokines in the pelvic environment, including IL-6, TNF-alpha, and IL-1 beta, alongside oxidative stress and immune-cell activity. His teaching considers antioxidant support in the wider discussion of pain and inflammatory pathways.…

…ocysteine → massive inflammation and cytokine storms (IL-6, TNF-α, IL-17, etc.). High homocysteine (>10-12 µmol/L; ideal <7-8) acts like a "cytokine amplifier," driving Th17 skewing, oxidative stress, low glutathione, and flares like fever…

…ol/L), homocysteine directly stimulates production of IL-6, TNF-α, IL-17, IL-1β, IL-8, and MCP-1—the exact Th17/Th1-dominant storm driving most autoimmune diseases. Recent meta-analyses confirm the link: MTHFR C677T and A1298C polymorphisms…

A compound made in the body that participates in the citric acid cycle and amino-acid metabolism.

Interpret relative to lipids when appropriate; assay-specific.

Explore the allergy response and the immune signals discussed in Dr. Purser’s alpha-gal report.

Explore macrophage inflammatory protein-1 alpha, CCR1, CCR5, and the recruitment of myeloid cells and lymphocytes.

Explore the p19 and p40 subunits, interleukin-23, and the difference between the IL23A gene and the IL23R receptor.

A subscriber post from Purser Wellness on Substack, covering cytokines and immune signaling.

A subscriber post from Purser Wellness on Substack, covering cytokines and immune signaling.

Dupilumab, sold as Dupixent, is a prescribed antibody medicine that acts on IL-4 receptor alpha.

One member of the vitamin E family; it is distinct from alpha-tocopherol, the form used to establish vitamin E requirements.