Encyclopedia

Explore interleukin-5, eosinophils, type 2 inflammation, genetic terminology, and treatment options.

Explore rs2910397, rs2637125, steroid sulfation, DHEA, DHEAS, bile acids, and hormone and liver pathways.

Dr. Purser’s subscriber report on IL-10 dysregulation, immune signaling, and his discussion of the VARS Antioxidant Triad.

Dan and Jackson discuss methylated B vitamins, the term overmethylation, and questions to ask when your response to a supplement changes.

Explore coagulation Factor XI, rs2289252, thrombin, fibrin, deep vein thrombosis (DVT), venous thromboembolism (VTE), and questions about treatment.

Dr. Purser’s subscriber report on IL-17, homozygosity, and the skin, joint, and digestive topics raised in the public introduction.

Dr. Purser’s subscriber report on COL5A1. Open the original publication to read the report with your Substack access.

Explore RAD50, the MRE11–RAD50–NBS1 (MRN) complex, DNA double-strand breaks, genomic stability, and related DNA-repair and antioxidant pathways.

Explore the reduced folate carrier (RFC1), rs3788200, rs1051266, intracellular folate, homocysteine, and folinic acid and methylfolate.

Explore rs1801406, BRCA2, DNA repair, cancer-risk interpretation, genetic counseling, and inflammatory signaling; your exact result needs a clinician’s interpretation.

Explore Toll-like receptor 4, lipopolysaccharide (LPS), HMGB1, innate immune sensing, and related inflammatory pathways.

Dan Purser MD and Jackson Larkin discuss the connections they consider between sugar cravings, cellular energy, and methylation.