Encyclopedia

A subscriber post from Purser Wellness on Substack, covering cytokines and immune signaling.

A subscriber post from Purser Wellness on Substack, covering cytokines and immune signaling, inflammation and antioxidants, gut and digestion.

A subscriber post from Purser Wellness on Substack, covering cytokines and immune signaling.

Why elevated soluble IL-2 receptor levels drive chronic inflammation and pain in sarcoidosis — and what actually helps quiet the fire

A subscriber post from Purser Wellness on Substack, covering cytokines and immune signaling, inflammation and antioxidants, mind, mood, and sleep.

A subscriber post from Purser Wellness on Substack, covering cytokines and immune signaling.

Explore interleukin-2, T cells, natural killer cells, immunotherapy, vascular leak syndrome, and effects on the immune system.

🧬 MTHFR Mutations, High Homocysteine & Autoimmune Disease: The Hidden Root Cause Most Doctors Miss For decades, patients with RA, lupus, MS, Hashimoto’s, and fibromyalgia chase symptom relief with meds that never fix the underlying fire. A

— A Guide by the World’s Leading Homocysteine Expert For more than four decades as a practicing physician, I have watched thousands of patients cycle through conventional autoimmune treatments that address symptoms but never touch the fire underneath. Rheumatoid arthritis flares, lupus rashes, multiple sclerosis relapses, Hashimoto’s thyroiditis, fibromyalgia pain—these are not random. They share a common, often overlooked biochemical pathway: MTHFR mutations leading to elevated homocysteine that supercharges autoimmune inflammation . This is not fringe theory. It is the clinical reality I hav

Most people have never heard of homocysteine , yet this small molecule may hold the key to understanding inflammation, cardiovascular disease, neurological problems, and many chronic conditions. For decades, homocysteine was viewed as a toxic substance in the blood. Doctors were taught that lowering it with B-vitamins might reduce heart disease risk. But research results were inconsistent, leaving many physicians unsure whether homocysteine truly mattered. New research and clinical observations are changing that view. We introduce a new framework called the Purser Model , which explains why ho

The Overlooked Link Between MTHFR Mutations, Hyperhomocysteinemia, PCOS, Fibromyalgia, Chronic Inflammation, and Renal Decline — and Why Precision Genetic Testing May Be the Missing Step

Dr. Purser shares his clinical perspective on homocysteine, methylation, and inflammatory patterns.