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…n fatty-acid metabolism. Also called: Fatty Acid Desaturase 2 / D6D The form of a fatty acid matters Dr. Purser teaches FADS genes as a conversion pathway. FADS2 participates in a delta-6 desaturase step in fatty-acid metabolism. This is wh…

FOLR2 encodes folate receptor beta, a folate-binding protein expressed in particular cell types, including subsets of immune cells. It is distinct from the FOLR1 receptor and the SLC19A1 reduced folate carrier. Also called: Folate Receptor …

FUT2 affects substances on the surfaces of the gut and other moist tissues and is studied in relation to the microbiome. Also called: Fucosyltransferase 2 The mucosal and microbiome connection Dr. Purser’s course places FUT2 in its gut–immu…

G6PC2 encodes a glucose-6-phosphatase-related protein expressed in pancreatic islet cells. Common variation is associated with differences in fasting glucose regulation; it is not the insulin receptor. Also called: Glucose-6-Phosphatase Cat…

GAD2 helps make GABA, a chemical messenger, from glutamate. Also called: Glutamate Decarboxylase 2 Another part of the GABA system GAD2 helps make GABA from glutamate. GAD1 does a related job, but the two genes are different. Check the exac…

…cuit, separate from AOC1-mediated clearance and the HRH1/HRH2 receptors that receive histamine signals. Putting the pieces together The reference discusses dietary patterns and clinician-selected antihistamine approaches in this section. Th…

…: IL-6, Interleukin 6 IL-6 links inflammatory and metabolic signals IL6 encodes interleukin-6, a cytokine involved in immune responses and acute-phase signaling. It can appear in discussions of infection, chronic inflammation and metabolic …

… called: MAO-B, Monoamine Oxidase B Breaking down monoamine signals MAOB encodes monoamine oxidase B, an enzyme involved in breaking down monoamine compounds, including dopamine. It does not simply build dopamine, and a DNA marker is not a …

NR3C2 encodes the mineralocorticoid receptor, which responds to hormones such as aldosterone and helps regulate salt and fluid balance. It is distinct from the NR3C1 glucocorticoid receptor. Also called: Mineralocorticoid Receptor / Nuclear…

PSEN2 encodes a presenilin protein that participates in gamma-secretase, a protein-processing complex. Some pathogenic variants can cause familial Alzheimer’s disease; a listed common marker is not equivalent to that diagnosis. Also called:…

SOD2 works in mitochondria as part of the body’s antioxidant defenses. Also called: Superoxide Dismutase 2 Superoxide defense in its own setting Dr. Purser teaches SOD as one member of an antioxidant team. SOD2 works in mitochondria and use…

…mmune disease or another cause of inflammation, and the genotype does not determine a measured TNF level. More from the teaching: Understanding inflammatory amplification Dr. Purser discusses TNF-alpha as an inflammatory messenger in the co…