…. Purser follows crystal recognition through NLRP3, caspase-1, and IL-1 beta into inflammatory-cell recruitment. This distinguishes the crystal trigger from the cytokines that carry the inflammatory message. Bring these questions to your v…
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What’s searchable?…thway Dr. Purser connects chemokines such as IL-8, CCL2/MCP-1, and CCL4 with Th1/Th17 signaling and cytokines including TNF-alpha, IL-6, and IL-1 beta. He discusses the interaction of immune-cell recruitment and tissue injury. Bring these …
…r. Purser connects endothelial changes, immune signals, TGF-beta-related fibrosis, and Raynaud’s phenomenon. Tissue scarring and inflammatory activity are related but do not mean every symptom has the same cause. Bring these questions to y…
…entation is approached Distinguish preformed vitamin A from beta-carotene and review existing multivitamin, liver/cod-liver-oil and eye-health products. Dr. Purser’s BCO1 teaching explains why conversion can be part of the discussion, but a…
…nt gene. Also called: DAO, Amine Oxidase, Copper Containing 1, Diamine Oxidase Histamine: making it, responding to it, clearing it Dr. Purser’s genetics reference places AOC1 in the histamine-clearance part of the gut and immune story. The …
ATG16L1 is involved in autophagy, a process that helps cells recycle parts. Also called: Autophagy-Related 16-Like 1 Cellular recycling meets gut immunity ATG16L1 is involved in autophagy, a process that helps cells recycle parts. It is stu…
BRCA1 helps repair damaged DNA. Clinically classified pathogenic variants can affect inherited cancer risk; a common SNP or a variant of uncertain significance is a different finding. Also called: Breast Cancer 1 DNA repair and inherited ca…
…building blocks for glutathione. Also called: Cystathionine Beta-Synthase From homocysteine toward glutathione Dr. Purser places CBS in the sulfur-handling pathway that connects homocysteine with glutathione production. In that map, CBS con…
COL5A1 encodes one component of type V collagen, which helps organize collagen fibers. It connects to the strength and structure of tendons, skin and other connective tissues. Also called: Collagen Type V Alpha 1 Chain Collagen structure, t…
ESR1 encodes estrogen receptor alpha, which helps cells respond to estrogen. Receptor signaling is different from the amount of estrogen measured in blood. Also called: Estrogen Receptor 1 Estrogen signaling depends on the receptor ESR1 enc…
…n fatty-acid metabolism. Also called: Fatty Acid Desaturase 1 / D5D The form of a fatty acid matters Dr. Purser teaches FADS genes as a conversion pathway. FADS1 participates in a delta-5 desaturase step in fatty-acid metabolism. This is wh…
FOLH1 helps break down folate from food so it can be absorbed. This is different from the MTHFR step. Also called: Folate Hydrolase 1 Folate handling begins before remethylation Dr. Purser’s genetic chapters include FOLH1 in folate handling…
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