…linicians to compare the gene pattern with current nutrient/redox findings and tolerance. It explicitly avoids describing a person as unable to detox. Different GST genes and different variants should not be assumed to have identical effect…
…of glutathione S-transferases. These enzymes participate in redox chemistry, with roles that differ from the better-known GSTM1 and GSTP1 pathways.
Also called: Glutathione S-Transferase Omega 1
An omega-family glutathione enzyme
GSTO1 belo…
…linicians to compare the gene pattern with current nutrient/redox findings and tolerance. It explicitly avoids describing a person as unable to detox. Different GST genes and different variants should not be assumed to have identical effect…
…linicians to compare the gene pattern with current nutrient/redox findings and tolerance. It explicitly avoids describing a person as unable to detox. Different GST genes and different variants should not be assumed to have identical effect…
…e production is one part of the circuit
The Purser genetics reference describes HDC as the enzyme step converting histidine to histamine. In the teaching map, this is the production side of the circuit, separate from AOC1-mediated clearance…
… an HLA-DQ protein that presents antigen fragments to CD4 T cells. HLA-DQ function depends on pairing with an HLA-DQB chain, so an isolated marker is not a complete HLA type.
Also called: HLADQA1, Human Leukocyte Antigen DQA1
Antigen presen…
…eptor H1
Receiving the histamine signal
The Purser genetics reference places HRH1 in the histamine-response part of the MCAS discussion. H1 receptors help mediate histamine effects; they are not the enzymes that make histamine or break it d…
…stamine also connects to stomach acid
Dr. Purser’s genetics reference connects HRH2 with histamine signaling and gastric acid secretion. H2 is a receptor, so this teaching concerns response to a signal rather than histamine production by HD…
…ing and gut immune activation. The receptor gene and a measured cytokine level are different kinds of information; a receptor variant does not tell you how much IL-23 is circulating.
More from the teaching: How Dr. Purser connects the piece…
…th B vitamins, magnesium, inositol, amino acids, omegas and redox findings. The purpose is to understand an individual pattern and tolerance. A gene result does not measure neurotransmitter levels or justify replacing psychiatric care with …
… an enzyme involved in breaking down components of the extracellular matrix. Controlled remodeling is part of repair, while excess activity can accompany inflammatory tissue damage.
Also called: Matrix Metallopeptidase 3
Remodeling the tiss…
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