Free PSA / total PSA — lab reference
In the reference guideOften used when total PSA is in an indeterminate zone. Use the performing-lab risk table.
THE PURSER WELLNESS LIBRARY
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What’s searchable?Often used when total PSA is in an indeterminate zone. Use the performing-lab risk table.
No single normal cutoff fits every patient. Use age, baseline, trend, prostate size, risk factors, and shared decision-making.
Correct for albumin when appropriate or measure ionized calcium.
Fasting, Gilbert syndrome, hemolysis, and liver disease may alter result.
Review albumin, globulin, and electrophoresis when indicated.
Screening measure, not a stand-alone treatment target.
Binding abnormalities and severe illness may affect some free-hormone assays.
Useful in selected hyperthyroid states; not a sensitive stand-alone test for hypothyroidism.
Affected by thyroid-binding globulin, pregnancy, estrogen, and medications.
Affected by binding proteins and nonthyroidal illness.
Interpret with iron, transferrin saturation, and ferritin.
No universal wellness target. Interpret with B12, folate, B6, kidney, thyroid, genetics, and medications.
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