Follow a question.
Find a connection.

Dr. Purser’s subscriber report on COL5A1. Open the original publication to read the report with your Substack access.

This report overview covers skin inflammation, dermal collagen, granulomas, and the cytokine pathways considered in the report.

This report overview covers high mobility group box 1, damage-associated molecular patterns (DAMPs), TLR4, RAGE, and cellular stress.

Dr. Purser explores glutathione, liver processing, antioxidant recycling, and the importance of considering the whole pathway.

This report overview covers RAD50, the MRE11–RAD50–NBS1 (MRN) complex, DNA double-strand breaks, genomic stability, and the DNA-repair and oxidative-stress pathways discussed in the source.

This report overview covers the reduced folate carrier (RFC1), rs3788200, rs1051266, intracellular folate, homocysteine, and the report’s discussion of folinic acid and methylfolate.

This report overview covers the source’s discussion of rs1801406, BRCA2, DNA repair, cancer-risk interpretation, genetic counseling, and inflammatory signaling; the overview does not establish a variant’s classification or personal cancer risk.

This report overview covers the NLRP3 sensor, inflammasome priming and activation, IL-1 beta, IL-18, and pyroptosis.

This report overview covers TNFSF10, TRAIL, DR4, DR5, apoptosis, immune surveillance, and the report’s discussion of cell-death signaling and treatment research.

This report overview covers pelvic inflammation, IL-6, symptoms, and the treatment comparisons discussed in the source report.

A subscriber post from Purser Wellness on Substack, covering cytokines and immune signaling, hormones.

This report overview covers Toll-like receptor 4, lipopolysaccharide (LPS), HMGB1, innate immune sensing, and the inflammatory pathways discussed in the report.